The destructive exploitation of agarwood has badly affected the wild population of all Aquilaria species. As a consequence, the genus is now listed as endangered species and protected under Convention on International Trade in Endangered Species of Wild Fauna and Flora regulation due to a drastic declination of the species in the wild Convention On International Trade In Endangered Species.

High demand for quality agarwood in conjunction with the depletion of the wild Aquilaria trees continues to present strong poaching pressures. The only viable alternative is the mass cultivation and of Aquilaria trees within managed plantations, which serve as a sustainable source to obtain agarwood have greatly resolved the shortage of agarwood supply in the global market.

Efforts to artificially induce the Aquilaria trees can be traced back to as early as 300 C.E. in Chinese history, where it was recorded that resin deposition accompanied with color changes of internal tissues can happen within a year by injuring the trees. Besides the mechanical wounding approach, the use of chemical, insect and pathogen-inducing techniques is increasingly common in the agarwood industry nowadays. All of these induction techniques in any case mimic the natural processes of agarwood formation, which have their own strengths and weaknesses.